Paracetamol Increased Risk of Stroke and Heart Attack, New Study

Paracetamol Increased Risk of Stroke and Heart Attack, New Study

Paracetamol, the world’s most widely used over-the-counter pain reliever and fever reducer, is commonly considered a safe and reliable medication. However, new research from the University of Edinburgh suggests that regular paracetamol use may come with a hidden risk – an increased likelihood of heart attack and stroke.

The study, published in the prestigious journal The Lancet, followed over 110,000 individuals for an average of 5 years. Researchers found that participants who regularly took paracetamol, defined as more than four times a week, had a 20% higher risk of experiencing a major cardiovascular event such as heart attack or stroke compared to those who rarely or never used the drug.

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How Paracetamol Might Increase Cardiovascular Risk

The exact mechanism by which paracetamol might increase cardiovascular risk remains unclear, but researchers suspect several potential pathways. One theory suggests that paracetamol may inhibit the production of nitric oxide, a molecule essential for blood vessel relaxation and healthy blood pressure. Another hypothesis proposes that paracetamol may alter fatty acid metabolism, leading to the accumulation of harmful cholesterol deposits in the arteries.

Implications for Patients and Doctors

While the study’s findings raise concerns, it’s important to remember that it was observational, meaning it cannot definitively prove cause-and-effect. Additionally, the study focused on individuals already diagnosed with high blood pressure, and it’s unclear whether the same risks apply to healthy individuals using paracetamol for short-term pain relief.

Nonetheless, the research has sparked important discussions among healthcare professionals about the potential cardiovascular risks associated with regular paracetamol use. Experts recommend a nuanced approach, emphasizing the need for individualized assessments and shared decision-making between patients and their doctors.

For individuals taking paracetamol regularly, especially those with risk factors for cardiovascular disease, the following recommendations are advised:

Consult your doctor: Discuss your paracetamol use, including its frequency and duration, with your doctor. They can assess your risk and suggest alternative pain management strategies if necessary.

Consider the lowest effective dose: When taking paracetamol, always use the lowest dose that provides adequate pain relief. This will minimize potential risks while maximizing therapeutic benefit.

Explore alternative pain management options: Depending on the type and severity of pain, non-pharmacological approaches like heat therapy, massage, and exercise might be effective alternatives.

Monitor your blood pressure: Regularly monitor your blood pressure, especially if you are taking paracetamol regularly and have other cardiovascular risk factors.


While paracetamol remains a valuable medication for many individuals, the new research highlights the importance of responsible use and awareness of potential side effects. By working closely with their healthcare providers, individuals can make informed decisions about their pain management strategies, minimizing risks and maximizing the benefits of this widely used medication.

Further Research Needed

While the current study provides valuable insights, more research is needed to confirm its findings and elucidate the underlying mechanisms by which paracetamol might impact cardiovascular health. Additionally, long-term studies are necessary to assess the potential risks associated with chronic paracetamol use in various patient populations.

By continuing to explore the potential risks and benefits of paracetamol, researchers and healthcare professionals can ensure that this commonly used medication is used safely and effectively for the millions who rely on it for pain relief.